effects of novel 2-alkylaminosubstituted dihydropyridines on rabbit jejunum
نویسندگان
چکیده
in order to investigate the effects of dimethylamino substituent at position 2 of the dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4- (l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously, dialkyl l,4-dihydro-2-[2-(dimethylamino)ethyl]-6-methyl-4-(l-benzyl-2- alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (6a-f) were synthesized. rabbit jejunum was used to determine the relaxant or antagonistic activity of the test compounds. the test compounds (6c-e) inhibited the spontaneous contractile activity dose-dependently and completely, while high-k+ contracted tissues were relaxed partially.
منابع مشابه
EFFECTS OF NOVEL 2-ALKYLAMINOSUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM
In order to investigate the effects of dimethylamino substituent at position 2 of the dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4- (l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously, dialkyl l,4-dihydro-2-[2-(dimethyla...
متن کاملEffects of 2-Alkylamino-Substituted Dihydropyridines on Rabbit Jejunum
In order to investigate the effects of dimethylamino substituent at postion 2 of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-(dimethy- lamino) ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicar- boxylates (6a-f) were synthesized. The synthesis was started from dialkyl 1,4- dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridine...
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in order to investigate the effects of dimethylamino substituent at postion 2 of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-(dimethy- lamino) ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicar- boxylates (6a-f) were synthesized. the synthesis was started from dialkyl 1,4- dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicar-...
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عنوان ژورنال:
medical journal of islamic republic of iranجلد ۱۸، شماره ۴، صفحات ۳۶۱-۳۶۴
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